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1994-2000      新加坡国立大学Loh Teck-Peng教授指导下获得化学理学学位和硕士学位
2000-2005      麻省理工学院师从Gregory Fu教授获得有机化学博士学位
2005-2008      耶鲁大学及后来在伊州大学香槟分校John Hartwig教授实验室接受博士后训练
2008-2019      南洋理工大学担任助理教授，高等研究科学家和新加坡国家研究基金会研究员
2019               北京大学深圳研究生院研究员

2008      Singapore National Research Foundation fellowship
2011-14      Asian Core Program Lectureship Award, 2011 Malaysia, 2012 Taiwan, 2013 Japan, 2014 China
2012      Thieme Chemistry Journals Award for young professors at early stages of academic career
2013      GSK-EDB Green and Sustainable Manufacturing Award, Singapore
2015      SPMS Young Researcher Award, Nanyang Technological University
2017      GSK-EDB Green and Sustainable Manufacturing Award, Singapore

2019       Bayer Investigator Award 拜耳研究者奖 

       我的研究主要集中在后过渡金属催化反应，研究重点是基元C-C键的不对称构建以及手性药物和有生物活性化合物的合成。最近的研究兴趣还包括光照下的金属催化，自由基参与的催化反应， 小环的不对称催化合成，含氟和含氘药物的不对称合成。正在进行的研究项目包括: 1）不对称Heck反应，2）不对称烯醇芳基化反应，3）钯催化烷基化反应，4）镍催化的不对称转移氢化反应，5）铜催化的不对称加成反应。
       作为通讯作者，已在 J Am Chem Soc 和 Angew Chem 上发表了30篇通讯论文。h-index 38. Citation 4300 (Google Scholar. 2021.4)

研究结果简介：
1. 开发了一种环烯的高手性选择性Heck反应催化剂，一种手性双膦单氧化物Xyl-SDP(O)。它具有优异的底物通用性、高活性和高立体选择性的特点 。新催化剂已由Sigma-Aldrich商业化。
2. 常见的末端烯烃在Heck反应中很难实现高区域选择性。我组开发了这种催化剂，首次实现这些烯烃的alpha位选择性芳基化。为此发明的二茂铁双膦配体DNPF已由Sigma-Aldrich商业化。
3. 开发了对映选择性烯醇芳基化反应，第一次在酯、酮和内酯alpha位上形成对碱敏感的叔碳手性中心。我组由此获得了一项合成消炎药Naproxen的美国专利。我们还首次报道了alpha氟酮和烷基腈的不对称芳基化反应。
4. 开发了钯催化下烯烃和普通卤代烷间的Heck型烷基化反应。 我组后来成功将该自由基烷基化反应用于多种贫电杂环和芳环化合物。
5. 不对称氢化反应已应用于手性药的大规模生产，但这些反应高度依赖非常昂贵且稀缺的稀有过渡金属催化剂，如铑和铱。制药工业迫切需要解决这个工艺的可持续性问题。我组已发明了一系列均相镍催化的不对称转氢化反应，底物包括烯、酮亚胺、肼等。
6. 在铜催化的芳基硼不对称加成反应中， 发现并证实首例金属催化中1，4-插入基元反应模式。

1. Copper-Catalyzed Asymmetric Arylation of N-Heteroaryl Aldimines: Elementary Step of a 1,4-Insertion.Chunlin Wu, Xurong Qin, Adhitya Mangala Putra Moeljadi, Hajime Hirao, Jianrong Steve Zhou* (HH contributed DFT calculation) Angew. Chem. Int. Ed. 2019, 58, 2705-2709.

2. Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates and a Phosphinamide via Nickel Catalysis. Xiaohu Zhao, Haiyan Xu, Xiaolei Huang and Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2019, 58, 592-596. Highlighted by Mark Lautens et al. in Synfacts 2019, 15(03), 0258

3. Palladium-Catalyzed Enantioselective Arylation of Racemic Ketones to Form Bridged Bicycles via Dynamic Kinetic Resolution. Xiaolei Huang, William Ray Jun Jie Oh and Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2018, 57, 7673-7677.

4. Palladium-Catalyzed para-Selective Alkylation of Electron-Deficient Arenes. Zhiwei Jiao, Li Hui Lim, Hajime Hirao and Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2018, 57, 6294-6298.

5. Nickel-Catalyzed N-Alkylation of both Acylhydrazines and Arylamines with Alcohols and Enantioselective Examples. Peng Yang, Caili Zhang, Yu Ma, Caiyun Zhang, Aijie Li, Bo Tang* and Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2017, 56, 14702-14706. Highlighted by Yamamoto et al. Synfacts 2018, 14(2), 164.

6. Asymmetric Intermolecular Heck reaction of Propargylic Acetates and Cycloalkenes to Access Fused Cyclobutenes. Zhiwei Jiao, Qi Shi, Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2017, 56, 14567-14571. Highlighted by Lautens et al. Synfacts 2018, 14(1), 48.

7. Nickel-Catalyzed Asymmetric Reductive Heck Cyclization of Aryl Halides to Access Indolines. Xurong Qin, Marcus Wen Yao Lee, Jianrong Steve Zhou* Angew. Chem. Int. Ed. 2017, 56, 12723-12726. Highlighted by Lautens et al. Synfacts 2017, 13(10), 1040.

8. Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles. Zhiwei Jiao, Kwok Wei Chee, Jianrong Steve Zhou* J. Am. Chem. Soc. 2016,138, 16240. One of most read JACS articles of the month. Highlighted by Yamamoto et al. Synfacts 2017, 13(3), 274.

9. Palladium-Catalyzed Enantioselective α-Arylation of α-Fluoroketones. Zhiwei Jiao, Jason Beiger, Yushu Jin, Shaozhong Ge, Jianrong Steve Zhou,* John F. Hartwig* J. Am. Chem. Soc. 2016, 138, 15980. One of most read JACS articles of the month. Highlighted by Lautens et al. Synfacts 2017, 13(2), 155.

10. Nickel-Catalyzed Enantioselective Reductive Amination of Ketones with Both Arylamines and Benzhydrazide. Peng Yang, Li Hui Lim, Pratanphorn Chuanprasit, Hajime Hirao,* Jianrong (Steve) Zhou* (HH contributed calculation) Angew. Chem. Int. Ed. 2016, 55, 12083.

11. Asymmetric Conjugate Addition of Organoboron Reagents to Common Enones Using Copper Catalysts. Chunlin Wu, Guizhou Yue, Christian Duc-Trieu Nielson, Kai Xu, Hajime Hirao,* Jianrong (Steve) Zhou* (HH contributed DFT calculation) J. Am. Chem. Soc. 2016,138, 742. One of the most read JACS articles of the month. Highlighted by Lautens et al. Synfacts 2016, 12(4), 394 and Organic Chemistry Portal in 2016.

12. Palladium-Catalyzed Direct Cyclopropylation of Heterocycles. Xiaojin Wu, Chuanhu Lei, Guizhou Yue, Jianrong (Steve) Zhou* Angew. Chem. Int. Ed. 2015, 54, 9601. Highlighted in Synform 2015, 12, A175.

13. Palladium-Catalyzed Asymmetric Reductive Heck Reaction of Aryl Halides. Guizhou Yue, Kaining Lei, Hajime Hirao, Jianrong (Steve) Zhou* Angew. Chem. Int. Ed. 2015, 54, 6531. One of the most accessed papers of the month in Angew Chem.