代表性成果
发表文章 （#：共同第一；*：共同通讯）
1. Fu Z#, Huang B#, Tang J#, Liu S#, Liu M, Ye Y, Liu Z, Xiong Y, Zhu W, Cao D, Li J, Niu X, Zhou H, Zhao YJ, Zhang G*, Huang H*, The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery, Nat Commun. 2021;12(1):488.
2. Ye Y#, Xiong Y#, Huang H., Substrate-binding destabilizes the hydrophobic cluster to relieve the autoinhibition of bacterial ubiquitin ligase IpaH9.8, Commun Biol. 2020;3(1):752.
3. Tang J#, Wang Y#, Zhou H#, Ye Y, Talukdar M, Fu Z, Liu Z, Li J, Neculai D, Gao J, Huang H, Sunitinib inhibits RNase L by destabilizing its active dimer conformation , Biochem J . 2020;477(17):3387-3399.
4. Daou S#, Talukdar M#, Tang J#, Dong B, Banerjee S, Li Y, Duffy NM, Ogunjimi AA, Gaughan C, Jha BK, Gish G, Tavernier N, Mao D, Weiss SR, Huang H*, Silverman RH*, Sicheri F*, A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency, Proc Natl Acad Sci U S A. 2020;117(40):24802-24812.
5. Huang H, Zeqiraj E, Dong B, Jha BK, Duffy NM, Orlicky S, Thevakumaran N, Talukdar M, Pillon MC, Ceccarelli DF, Wan LC, Juang YC, Mao DY, Gaughan C, Brinton MA, Perelygin AA, Kourinov I, Guarné A, Silverman RH, Sicheri F, Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon induced antiviral activity. Mol. Cell. 2014; 53, 221-34
Recommended in F1000, http://f1000.com/prime/718246713;
Highlighted in Cell 157, 2014: http://www.cell.com/cell/pdf/S0092-8674(14)00487-5.pdf）
6. Huang H*, Ceccarelli DF*, Orlicky S*, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F, E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nat. Chem. Biol. 2014 10, 156-63
7. Fradet-Turcotte A, Canny MD, Escribano-Díaz C, Orthwein A, Leung CC, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F, Durocher D. 53BP1 is a reader of the DNA-damage-induced H2A Lys15 ubiquitin mark. Nature. 2013, 499, 50-54.
8. Rivkin E, Almeida SM, Ceccarelli DF, Juang YC, MacLean TA, Srikumar T, Huang H, Dunham WH, Fukumura R, Xie G, Gondo Y, Raught B, Gingras AC, Sicheri F, Cordes SP. The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature. 2013, 498, 318-24
9. Huang H and Vogel HJ, Structural Basis for the Activation of the Cytoplasmic Domain of the Human Platelet Integrin AlphaIIb-beta3 by CIB1. J. Am. Chem. Soc., 2012, 134, 3864-72（Highlighted in Science Daily， http://www.sciencedaily.com/releases/2012/03/120319095011.htm）
10. Huang H, Ishida H, Yamniuk, AP, Vogel HJ, The Solution Structures of Ca2+- CIB1 and Mg2+-CIB1 and
their interactions with the Platelet Integrin αIIb Cytoplasmic Domain. J. Biol. Chem., 2011, 286, 17181-92
发明专利
Tyers M, Sicheri F, Ceccarelli DF, Huang H, et al., Screening methods to identify compounds inhibiting the activity of E2 enzymes by stabilization of non-covalent ubiquitin-E2 complexes and pharmaceutical applications related to E2 inhibitors. Application #: PCT/CA2013/001079;
黄昊; 张国良; 汤金乐; 刘淑燕; 付子阳; 刘明; PLpro蛋白抑制剂在治疗和预防新型冠状病毒感染的药物中的应用, 2020-6-8, 中国专利, 202010511707.4.
